Paramyotonia Congenita greatly affects the body.
At the cellular level, PMC causes the sodium channels to fail to regulate the flow of ions properly. So, the ratio of sodium and potassium inside and outside the cell become unbalanced.
At the tissue level, the unbalanced ration of ions causes muscle fiber to contract uncontrollably when the signal to contract arrives.
At the organ level, as the imbalance worsens, muscle stops responding to nerve signals.
At the organ system level, as the muscle stops responding to nerve impulses, the muscle system becomes stiff. This results in muscle weakness and paralysis.